Maintaining healthy blood glucose
(sugar) levels is the cornerstone of diabetes management. However, data
increasingly shows that for diabetes patients 65 and older, aiming for very low
daily blood sugars or A1C (average blood glucose over several months) levels
may not provide benefits, and may even cause harm.
As the authors of a JAMA Internal
Medicine study put it, "Older persons, particularly those with complex
medical problems, may derive less benefit from intensive strategies to lower
glucose levels and are more susceptible to hypoglycemia [low blood sugar] and
its consequences than younger, healthier persons."
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Diabetes and Hypoglycemia
"Hypoglycemia can be severe,
both for young and old patients," says Amber Taylor, MD, Director of
Diabetes at The Center for Endocrinology at Mercy
Medical Center
in Baltimore .
"In older patients or those with multiple co-existing conditions,
hypoglycemia has been linked with increased falls, seizures, unconsciousness,
911 calls, and visits to the emergency room. The physiologic stress of
hypoglycemia [the way the body responds to the condition] can also cause
cardiac problems, especially risk of heart attack and death."
In the one study (the Diabetes
Control and Complications Trial), people receiving intensive treatment to
achieve tight blood sugar control had three times as many hypoglycemic
reactions other study participants.
In addition, the American Diabetes
Association (ADA)’s 2015 Standards of Care notes that there’s a lack of
long-term studies demonstrating the benefits of tightly controlled blood sugar,
blood pressure, and lipid (blood fats, like cholesterol) levels, especially in
patients with complications and co-existing conditions. The Standards of Care
also acknowledges the complicated nature of caring for older diabetes patients,
whom the ADA says make up about 26 percent of
seniors in the U.S.
A Different Approach
So for older adults, less
intensive, more individualized blood sugar goals may make more sense than
common treatment targets like A1C levels between 6.5 and 7 percent; those goals
may be more appropriate for younger, healthier people. Furthermore, Taylor says, heart
disease is a significant risk factor for diabetes patients, regardless of how
well they control their A1C levels, so managing these risk factors is a good
strategy.
"Tighter glycemic control has
been shown to prevent some of the circulatory [heart, blood, and blood vessel]
complications of diabetes, including damage to tiny blood vessels in the eyes
and kidneys, and nerves in the hands and feet," says Taylor . "Unfortunately, no matter how
tightly you control the A1C, patients with diabetes still have an increased
risk of cardiovascular [heart and blood vessel] disease. This is best minimized
with proven risk factor management, such as quitting smoking, controlling blood
pressure, and, in most patients, using anti-cholesterol medication with statin
therapy. Decreasing the risk of cardiac disease is more likely to have
long-term benefit than tight glycemic control."
The bottom line is that higher
blood sugars can be acceptable for older diabetes patients: "Patients who
take medications that cause hypoglycemia, or who suffer from hypoglycemia,
should talk to their primary physician or endocrinologist about their
individual glycemic targets," Taylor
says. "A safer medication might decrease their risk. Most patients with
diabetes should also take medicine for blood pressure and cholesterol to help
prevent cardiovascular disease. Healthy diet and exercise are also important as
part of good lifestyle maintenance."sign up for free Newletters
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